Stability-Indicating Method for the Determination of Bromazepam via Its Mercury(II), Silver(I) and Zirconium(IV) Chelates

Abstract

An accurate method is investigated for the selective determination of intact bromazepam (Ia) in the presence of its acid – induced degradation products, 2-amino-5-bromobenzoylpyridine (Ib) and glycine. The method is based on the chelation of bromazepam with mercury (II), silver (I) or zirconium (IV) to form chelates that absorb at 363 nm, 287 nm and 289 nm, respectively. The three proposed procedures determine 16 – 80 μg ml⁻¹, 8 – 48 μg ml⁻¹ and 6.4 – 38 μg ml⁻¹ of bromazepam, with mean accuracies of 100.1 ± 0.8%, 99.7 ± 0.7% and 100.3 ± 0.7%, respectively.

Key Words:

• Benzodiazepines
• Bromazepam Stability
• Indicating
• Metal Chelates.