Study on the Inclusion Properties of Charged β-Cyclodextrin as a Host Molecule by Fluorimetry

Shao-min Shuang Light Ind. and Chem.Eng.Res.Inst., South China Univ. of Tech., Guangzhou, 510641, China

Si-yuan Guo Light Ind. and Chem.Eng.Res.Inst., South China Univ. of Tech., Guangzhou, 510641, China

Jing-hao Pan Department of Chemistry, Shanxi University, Taiyuan, Shanxi, 030006, China

Lin Li Light Ind. and Chem.Eng.Res.Inst., South China Univ. of Tech., Guangzhou, 510641, China

Miao-yan Cai Light Ind. and Chem.Eng.Res.Inst., South China Univ. of Tech., Guangzhou, 510641, China

Abstract

The inclusion behavior of carboxymethyl-β-CD(CM-β-CD) with the drug procaine hydrochloride has been examined by using steady-state fluorescence measurements. Experimental conditions including CM-β-CD concentration and media acidity were investigated for the inclusion formation. The formation constants of inclusion complex were determined at different pH values. 1:1 (CM-β-CD/procaine) stoichiometry has been confirmed. The results suggest that CM-β-CD is suitable for including basic drugs based on additional electrostatic interactions different from the parent β-CD.

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Study on the Inclusion Properties of Charged β-Cyclodextrin as a Host Molecule by Fluorimetry

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Study on the Inclusion Properties of Charged β-Cyclodextrin as a Host Molecule by Fluorimetry

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