Optimization in the Formaldehyde Determination at Sub-PPM Level from Acetals by HPLC-DAD

ABSTRACT

Determination of formaldehyde at sub-ppm level as impurity in acetals using HPLC-DAD is described. Automated on-line precolumn derivatization reaction with 2,4 dinitrophenylhydrazine has been used. Breakdown rates of some industrial scale used acetals (Methylal, Ethylal) to formaldehyde by hydrolysis in aqueous media, according to pH, are described.

Keywords::

• HPLC-DAD
• formaldehyde
• Methylal
• Ethylal
• 2,4-dinitrophenylhydrazine