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Original Articles

Analytical Resolution of 4-ARYL-1,2,3,4,5,6,7,8-Octahydroquinazoline-2-Thiones using a Cellulose Chiral Stationary Phase

Pages 1245-1254 | Published online: 18 Feb 2008
 

ABSTRACT

Racemic 4-aryl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-thiones were resolved into their enantiomers by HPLC on cellulose tris(4-methylbenzoate) coated on silica gel using ethanol:n-hexane (70:30) as a mobile phase. A convenient method for preparation of cellulose tris(4-methylbenzoate) chiral stationary phase was described and the enantiomers were characterized by some chromatographic data.

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