An Improved Capillary Gas Chromatography Method for Triethylamine. Application to Sarafloxacin Hydrochloride and GnRH Residual Solvents Testing

ABSTRACT

A capillary gas chromatography (GC) method for residual solvents in the veterinary antibacterial compound sarafloxacin hydrochloride included triethylamine (TEA). Despite the use of commercially available deactivated columns and inlet liners, the peak shape and reproducibility for the TEA peak were very poor. The use of glass inlet liners and glass wool which were treated with methanolic potassium hydroxide resulted in marked improvement for TEA. This method was also used to determine residual TEA in the polypeptide GnRH.

Keywords::

• Capillary gas chromatography
• Triethylamine
• Residual solvents
• Validation