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A novel fiber-optic DNA biosensor based on chemiluminescence is proposed. DNA probes were covalently immobilized onto the distal end of the optical fiber bundle. Hybridization of HRP (horseradish peroxidase)-labeled complementary nucleotides to the immobilized probes was detected by enhanced chemiluminescence. The detection limit (S/N=3) is 0.1 ppm. The approach is shown to be specific, sensitive and capable of diagnostic applications.
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