A complement fixation test for visceral leishmaniasis using homologous parasite antigen I

W. T. HockmeyerWalter Reed Project, Kenya Institute for Medical Research and Veterinary Research Laboratory, Nairobi, Kenya

B. T. WelldeWalter Reed Project, Kenya Institute for Medical Research and Veterinary Research Laboratory, Nairobi, Kenya

C. L. SabwaWalter Reed Project, Kenya Institute for Medical Research and Veterinary Research Laboratory, Nairobi, Kenya

D. H. SmithDepartment of Tropical Medicine, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA

P. H. ReesDepartment of Medicine, University of Nairobi, Nairobi, Kenya

P. A. KagerDepartment of Medicine, University of Nairobi and Medical Research Center, Nairobi, Kenya

Abstract

The complement fixation test using homologous parasite antigen was evaluated in 60 individuals with confirmed visceral leishmaniasis and compared with the results obtained in individuals with other parasitic and infectious diseases; 88% of the confirmed cases of visceral leishmaniasis were positive whilst no positive reactions were observed in individuals with other infectious and parasitic diseases.

The specificity was partially compromised by anticomplementary activity in 5%, limited to individuals with visceral leishmaniasis, and doubtful (2%) or sero-negative (7%) results.

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A complement fixation test for visceral leishmaniasis using homologous parasite antigen I

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A complement fixation test for visceral leishmaniasis using homologous parasite antigen I

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