Effects of combinations of quinoline-containing antimalarials on Plasmodium falciparum in culture

T. G. GearyDepartment of Microbiology and Public Health, Michigan State University, East Lansing, MI48824-1101, U.S.A.

L. C. BonanniDepartment of Microbiology and Public Health, Michigan State University, East Lansing, MI48824-1101, U.S.A.

J. B.JensenDepartment of Microbiology and Public Health, Michigan State University, East Lansing, MI48824-1101, U.S.A.

H. GinsburgDepartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem91904, Israel

Abstract

Combinations of mefloquine, quinine, amodiaquine, chloroquine and 3-methylchloroquine were tested against chloroquine-resistant and -sensitive strains of Plasmodium falciparum in culture. All these drugs had purely additive interactions in both strains, except for mefloquine. Combinations of mefloquine with any of the other drugs always resulted in subadditive or inhibitory action.

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Effects of combinations of quinoline-containing antimalarials on Plasmodium falciparum in culture

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Effects of combinations of quinoline-containing antimalarials on Plasmodium falciparum in culture

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