The chemotherapy of rodent malaria XLI

Causal prophylaxis Part V. Effect of mefloquine on exoerythrocytic schizogony in Plasmodium yoelii yoelii

Y. BoulardLaboratoire de Zoologie-Vers, LA 114-CNRS, Museum National d'Histoire Naturelle, 61 rue Buffon, 75231Paris Cedex 05, France

I. LandauLaboratoire de Zoologie-Vers, LA 114-CNRS, Museum National d'Histoire Naturelle, 61 rue Buffon, 75231Paris Cedex 05, France

F. MiltgenLaboratoire de Zoologie-Vers, LA 114-CNRS, Museum National d'Histoire Naturelle, 61 rue Buffon, 75231Paris Cedex 05, France

W. PetersDepartments of Medical Protozoology and Electron Microscopy, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC IE 7HT, U.K.

D. S. EllisDepartments of Medical Protozoology and Electron Microscopy, London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC IE 7HT, U.K.

Abstract

Previous studies using mefloquine in rodents have suggested that this compound has no effect on pre-erythrocytic schizogony. In the present study, direct observations on 46-hour-old pre-erythrocytic schizonts of P. yoelii in the liver of rats have shown that mefloquine does induce recognizable changes in the peripheral, enzyme-containing vesicles but that these are insufficient to hinder the maturation of the parasites, thus confirming that this compound has no causal prophylactic value.

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The chemotherapy of rodent malaria XLI

Causal prophylaxis Part V. Effect of mefloquine on exoerythrocytic schizogony in Plasmodium yoelii yoelii

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The chemotherapy of rodent malaria XLI

Causal prophylaxis Part V. Effect of mefloquine on exoerythrocytic schizogony in Plasmodium yoelii yoelii

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