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Abstract
The sera of active and treated cases of kala-azar were tested for circulating immune complexes (CIC) by antigen-specific enzyme linked immunosorbent assay (ELISA). All (100%) of proved cases had elevated CIC; 64·3% of clinically diagnosed cases and 58·8% of treated cases were also positive for CIC. A fall in the level of CIC was observed after treatment. Detection of antigen-specific CIC may be useful in monitoring the therapeutic effect and recovery.