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Abstract
Single and repeated experimental human exposures to tefrachioroethyîene vapor at a concentration of 100 ppm íor periods of seven hours to a five-day work week were conducted. Twenty-five percent of the subjects reported untoward subjective responses, while a small percentage were observed to exhibit early signs of central nervous system depression. Those subjects repeatedly exposed had fewer subjective and objective findings than the group exposed for one seven-hour period.
Analysis of the expired breath of the human subjects by infrared or gas chromatographic techniques provided a means by which to unequivocally establish a diagnosis of exposure. Serial measurements of the amount of solvent present in the breath permitted the construction of a curue which should be useful in estimating a worker’s exposure.