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Abstract
A mucoevacuant solution containing 0.125% tyloxapol (Superinone), 2% sodium bicarbonate, and 5% glycerin was delivered at graded doses to young cats via individual glass nebulizers and face masks. Effects on mucus flow and total respiratory tract fluid (RTF) volumes on normal animals and those with respiratory disease were evaluated. Significant increases in mucus flow rates occurred at 20 and 60 minutes on exposure to 133 to 798 mg per kg. Cats with viscid mucus and reduced flow were more amenable to inhalation therapy than those with watery mucus. Overdosage (9.6 gm/kg) caused no discernible changes in flow. Respiratory tract fluid output was enhanced by mucoevacuant with no statistical differences in volume output between normal and pathological cats. Particles sampled during exposure indicated respirable particles (5μ to 20μ).