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Abstract
Human volunteers were exposed to carbon monoxide at concentrations ranging from 1 to 1,000 ppm for 0.50 to 24 hours. Carboxyhemoglobin (COHb) levels greater than 20% produced changes in the visual evoked response similar to those previously described in animals. The amplitude of the 2–3–4 wave complex was increased and was accompanied by a negative-going shift in the 5a-6 waves. Carboxyhemoglobin levels approaching 33% did not alter gross spontaneous electroencephalographic activity.