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Abstract
Antineuraminidase antibody levels were mea.. sured by inhibition of hemagglutination employing recombinant strain X-15 in paired sera of human subjects naturally infected with influenza AO, and A2, strains and in sets of sera obtained from persons vaccinated with swine, AO, A1, or A2 monovalent vaccines. The antineuraminidase antibody increase found with the X-15 test after infection and vaccination was shown to be subtype specific for A2 enzymes. The frequency and mag.. nitude antibody increase after both types of antigenic experience was similar. An ether-extracted hemagglutinin vaccine was, as efficient as its whole virus counterpart in stimulating antienzyme antibodies. Reinforcement of antienzyme antibody levels and antigenic broadening of the antibody response on repeated exposures was demonstrated.