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Abstract
The rate of inactivation of purified poliovirus was determined at 113 F (45 C) in Ihe presence of various concentrations of magnesium ions. The rates could be predicted over a 50-fold range of magnesium ion concentrations from the expression, log V0/V = t k/KMn + 1. The latter was derived assuming that a fraction of the virus reacts with the cation to form a complex completely stable at 113 F (45 C). The data could be described by a Hill-type equation wherein the logarithm of a function of the degree of inhibition of viral inactivation was found to bear a linear relalionship to the logarithm of the concentration of magnesium ion. The interpretation of this plot is that the rale of inactivation of poliovirus at 113 F (45 C) is determined largely by a single vital reaction which can be blocked by a single magnesium ion.