3
Views
4
CrossRef citations to date
0
Altmetric
Original Articles

Further Characterization of the Specificity of Lung-Reactive Antibodies in Human Serum

&
Pages 502-507 | Received 05 Jan 1970, Accepted 11 Apr 1970, Published online: 30 Apr 2013
 

Abstract

Collagenase digestion of lung fibroblast antigen preparations was shown to destroy their antigenic reactivity in most instances when reacted with lung-reactive antibodies. In other instances, elastase digestion rendered the preparation nonreactive. Such a finding demonstrates that collagen and/or elastin are the major components involved in this reactivity. This was also supported by sensitizing the fibroblast with rabbit antihuman lung coUagen and demonstrating an inhibition when these same fibroblasts were used in the antiglobulin consum,ption test with known lungoe reactive sera. The use of fibroblast cells as antigens in other serological tests was also, studied. Cytotoxicity tests showed definite cytopathic effect when conducted with lung-reactive sera. Similar cytopathic changes were not noted with sera from either chronic disease patients or the control sera.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.