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Abstract
In the rat the toxic actions of various pesticides such as ethion, dioxathion (Navadel), EPN, azin-phosmethyl, and parathion are markedly, and often totally, inhibited by such typical catatoxic steroids as ethyiestrenol, SC-11927, spironolactone, and norbolethone. To a lesser extent this is also true of oxandrolone, prednisolone, and progesterone, which also proved to be somewhat less potent in detoxicating other substrates. Triamcinolone, desoxycorticosterone, hydroxydione sodium succinate, estradiol, and thyroxine, previously shown to be essentially devoid of any catatoxic activity, also failed to offer consistent protection against the pesticides just mentionedm DDT, physostigmine sulfate and pralidoxime chloride, tested for comparative purposes, proved to be much more resistant against detoxication by even the most powerful catatoxic steroids,. Many pesticides are highly amenable to detoxication by potent catatoxic steroids,. This detoxicating effect is independent of the classic hormonal properties of the steroids examined.