Distribution of ³⁵S in the Blood and its Excretion in Urine of Dogs Exposed to ³⁵SO₂

Eiji Yokoyama MD Department of Physiology and Environmental Health Sciences, Harvard School of Public Health, Boston, USA; Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, USA

Robert E. Yoder PhD Department of Physiology and Environmental Health Sciences, Harvard School of Public Health, Boston, USA; Lawrence Radiation Laboratory, University of California, Livermore, USA

N. Robert Frank MD Department of Physiology and Environmental Health Sciences, Harvard School of Public Health, Boston, USA; Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle, USA

Abstract

Blood ³⁵S levels in anesthetized dogs rose progressively when the isolated upper airways were exposed to ³⁵SO₂ for 30 to 60 minutes, and decreased slightly in the hours following exposure. The plasma contained more ³⁵S than the red blood cells (RBC); more than half of the plasma-³⁵S was dialyzable, the greatest radioactivity among the nondialyzable fraction of the plasma being associated with α-globulin proteins. Two thirds of the RBC-³⁵S appeared to be intracellular. RBC-³⁵S/Plasma-³⁵S was higher following in vivo exposure of animals than when plasma- ³⁵S was mixed with nonradioactive RBC. Most of the urinary ³⁵S was in the form of inorganic sulfate.

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Distribution of ³⁵S in the Blood and its Excretion in Urine of Dogs Exposed to ³⁵SO₂

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Distribution of ³⁵S in the Blood and its Excretion in Urine of Dogs Exposed to ³⁵SO₂