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Abstract
Female mice were given a single intravenous injection of alloxan (60 or 80 mg/kg body weight) and caged with normal males when the blood glucose levels rose significantly. The morning when a vaginal plug was found was designated as day 0.5 of pregnancy. Blastocysts were recovered after sacrifice of mothers on day 3.5 of gestation. Cytogenetic examinations of these embryos were made after air-drying of eggs, and the findings were compared with those observed in embryos taken from control groups. A marked decrease in the number of viable embryos recovered from diabetic pregnant mice was observed. Chromosomal analysis revealed a high incidence of polyploidy and aneuploidy in eggs from the diabetic group as compared with those from controls.