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Abstract
This study deals with respiratory tract retention of inhaled acetaldehyde vapor by dogs. Experiments were designed to measure uptake by the entire respiratory tract and by upper and lower portions and the influence of tidal volume and! of concentration Inhaled, A prime objective was to determine whether respiratory uptake of acetaldehyde in an animal system is comparable to previously reported human respiratory uptake. If so, this would make more meaningful additional types of experiments with acetaldehyde and other compounds in dogs alone. Total respiratory tract retention of acetaldehyde in dogs was found to be very close to human retention values and inversely related to ventilatory rate In the same manner. Uptake was also found to be higher in the upper tract than the lower tract and no related to changes in concentration inhaled or tidal volume.
