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Abstract
An association between softness of municipal drinking water and an increase in cardiovascular disease has been repeatedly reported from several different countries. Lead and copper have both been reported to be increased in soft water and have been suggested as possible etiologic agents. Therefore, autopsy tissue was obtained and analyzed for these two metals. Fifty-five persons without and 46 persons with definite ischemic heart disease were studied. Renal lead was not significantly different. Hepatic copper was increased (P=.05) in subjects with ischemic heart disease in the absence of diabetes or hypertension.