Neuromuscular Function, in Agricultural Workers Using Pesticides

Abstract

One hundred and two male agricultural workers who used pesticides underwent electromyographic (EMG) examination for signs of disturbed peripheral nerve and muscle function. In approximately 40%, abnormal EMG patterns were observed, similar to those found in myasthenic patients overtreated with neostigmine methylsulfate and pyridostigmine bromide and in male pesticide-factory workers exposed to mixed organophosphorus and organochlorine compounds. Fifty-three men were reexamined two months later and in 25 the EMG pattern changed either from abnormal to normal, or vice versa. Concurrent measurement of blood cholinesterase activity showed no difference between men with normal and abnormal EMG records; and all values were within normal limits, as were a number of biochemical blood measurements related to hepatic and renal function. No special causal agents were identified and no dosageresponse relationship was established.