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Original Articles

Activities of Pentose Shunt and Glycolytic Enzymes in Lungs of Ozone-Exposed Rats

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Pages 205-208 | Received 20 Jul 1972, Accepted 15 Sep 1972, Published online: 02 May 2013
 

Abstract

After seven days of exposure of rats to 0.8 ppm ozone, the activities of pentose shunt and glycolytic enzymes of the lungs were significantly increased, α-Tocopherol partially retarded the elevation of glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-P-GD), and malic enzyme, but not of others. In a separate exposure of rats to 0.75 ppm ozone, the activities of glutathione (GSH) peroxidase, GSH reductase, G-6-PD, 6-P-GD, and pyruvate kinase decreased initially and then increased above their respective controls. The results can be partially attributed to increased needs of reductive detoxification of lipid peroxide. Increased activities may be related to the development of adaptation by the animals.

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