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Original Articles

Lifelong Exposure of SPF Rats to Automotive Exhaust Gas

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Pages 264-269 | Received 15 Jun 1972, Accepted 08 Dec 1972, Published online: 02 May 2013
 

Abstract

Pathogen-free Sprague-Bawley rats (SPF) were exposed to automotive exhaust gas from 2 ½ months to lifetime (two years) for six hours per day, five days each week. The exhaust gas contained 50 ppm of carbon monoxide and two different concentrations of nitrogen oxides (NOx) (0.2 and 23.0 ppm), carbon dioxide (0.065% and 0.370%), and aldehydes (0.1 and 2.0 ppm). Only the dilution with the highest content of NOx (23 ppm) produced biological effects: decrease of body weight, diminution of the sound avoiding reflexes, and increase in the number of spontaneous tumors. However, this dilution does not influence heart rate, ventricular complex (QRS) II electrocardiographic deflection, the rats’ survival, or the renal and aortic lesions resulting from aging processes, although the emphysematous process may be accelerated.

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