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Abstract
The biological effects of the addition of 330±110μg/cu m of aerosolized sodium chloride (NaCI) crystals to approximately 2 ppm nitrogen dioxide (NO2) were studied in monkeys (Macaca speciosa) and rats by comparing them with effects of NO2 and NaCI aerosol individually. Following 14 months of continuous exposure, the respiratory bronchiolar epithelium was hypertrophic to similar degrees in monkeys exposed to NO2 with or without the NaCI aerosol, whereas animals exposed to the NaCI aerosol were not different from controls. Marginal results were observed in rats exposed to approximately half the concentrations of NO2 and NaCI. Animals exposed to NO2 with and without NaCI, developed polycythemia, with reduced mean corpuscular volume and approximately normal mean corpuscular hemoglobin concentration. Under the conditions of the experiment, the presence of NaCI crystals in the atmosphere did not alter the responses to NO2.