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Abstract
To elicit the “degreaser’s flush,” ethanol was administered to seven male volunteers who were repeatedly exposed to trichloroethylene (TCE) vapor. In six exposed subjects transient vasodilatation of superficial skin vessels occured after the ingestion of small amounts of ethanol (<0.5 ml/kg body weight).
The dermal response reached maximum intensity 30 minutes after its onset and then faded completely within 60 minutes. The skin vasodilatation appeared in symmetrical patterns on the face, neck, shoulders, and back.
The mechanism responsible for the vasodilatation is unknown, but two factors appear necessary before the dermal response can be elicited: (1) repeated exposures to TCE and (2) ingestion of a beverage containing alcohol.