Long-Term Effect of Benzene in C57BL/6N Mice

Jerrold M. Ward DVM, PhD Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Md

John H. Weisburger PhD Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Md; American Health Foundation, New York

Richard S. Yamamoto ScD Experimental Pathology Branch, National Cancer Institute, Bethesda, Md

Timothy Benjamin Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Md

Carolyn A. Brown MS Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Md

Elizabeth K. Weisburger PhD Carcinogen Metabolism and Toxicology Branch, National Cancer Institute, Bethesda, Md

Abstract

Weanling male C57BL/6N mice received repeated subcutaneous injections of benzene in corn oil for 54 weeks.

These mice and surviving controls were killed 104 weeks after the first injection. There was no evidence of carcinogenic activity in benzene-injected mice. A high incidence of amyloidosis developed in mice of all treated and untreated groups. Butylnitrosourea, used as a positive control, induced lymphomas or leukemias (in most exposed mice) and intestinal tumors in a few.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Long-Term Effect of Benzene in C57BL/6N Mice

Information for

Open access

Opportunities

Help and information

Long-Term Effect of Benzene in C57BL/6N Mice

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature