Inhalation Carcinogenicity of Alpha Halo Ethers

III. Lifetime and Limited Period Inhalation Studies With Bis(Chloromethyl)Ether at 0.1 ppm

Marvin Kuschner MD Institute and Department of Environmental Medicine and the Department of Pathology, New York University Medical Center, New York; State University of New York, Stony Brook, NY

Sidney Laskin MD Institute and Department of Environmental Medicine and the Department of Pathology, New York University Medical Center, New York

Robert T. Drew PhD Institute and Department of Environmental Medicine and the Department of Pathology, New York University Medical Center, New York; National Institute of Environmental Health Sciences, Research Triangle Park, NC

Vincent Cappiello MS Institute and Department of Environmental Medicine and the Department of Pathology, New York University Medical Center, New York; Lederle Research Laboratories, Pearl River, NY

Norton Nelson PhD Institute and Department of Environmental Medicine and the Department of Pathology, New York University Medical Center, New York

Abstract

Rats and hamsters were exposed to 0.1 ppm bis(chloromethyl)ether (BCME) six hours per day, five days per week throughout their lifetime. Additional groups of rats were given 10, 20, 40, 60, 80, and 100 exposures to 0.1 ppm BCME and then held until death.

Forty cancers originating in the respiratory tract were found in the 200 rats involved in these studies. These included 14 cancers of the lung and 26 cancers of the nasal cavity. They occurred in dose-related fashion.

A single undifferentiated carcinoma of the lung was seen in a hamster.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Inhalation Carcinogenicity of Alpha Halo Ethers

III. Lifetime and Limited Period Inhalation Studies With Bis(Chloromethyl)Ether at 0.1 ppm

Information for

Open access

Opportunities

Help and information

Inhalation Carcinogenicity of Alpha Halo Ethers

III. Lifetime and Limited Period Inhalation Studies With Bis(Chloromethyl)Ether at 0.1 ppm

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature