Lead

Possible Toxicity in Urban vs Rural Rats

David Mouw PhD Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI; Department of Environmental and Industrial Health, School of Public Health, the University of Michigan, Ann Arbor, MI

Kenneth Kalitis Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Miriam Anver DVM, PhD Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Joyce Schwartz Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Anna Constan Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Rolf Hartung PhD Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Bennett Cohen DVM, PhD Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

Dan Ringler DVM Department of Physiology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Medical Sciences Building, 48104, Ann Arbor, MI

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Abstract

The degree of lead poisoning in wild rats from two environments has been studied. Wild rats captured in an urban area had markedly elevated tissue lead compared with values in rural rats. This elevation may have been caused by differences in factors affecting absorption of ingested lead or an elevated respiratory exposure to airborne lead, or both, and lead in precipitated dust.

Changes in several biologic indexes (depression of Δ-amino levulinic acid dehydratase in kidney and red blood cells, presence of renal intranuclear inclusion bodies, and increased kidney weight) confirmed lead-poisoning in urban rats.

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Lead

Possible Toxicity in Urban vs Rural Rats

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Possible Toxicity in Urban vs Rural Rats

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