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Abstract
Rabbits were exposed for four minutes to combinations of oxygen (21%, 11%, or 7%) and fluorocarbon-11 (0%, 5%, or 15%). Exposure to 7% oxygen-15% fluorocarbon-11 caused cardiac arrhythmias in all rabbits exposed. These bradyarrhythmias developed at levels of arterial hypoxemia that did not cause arrhythmias in rabbits exposed to 7% oxygen alone.
In contrast with recent reports, hypoxia and this aerosol propellant do appear to have an interactive effect on cardiac rhythm.