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Archives of Environmental Health: An International Journal Volume 30, 1975 - Issue 7
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Original Articles

Short-Term Effects of Cigarette Smoking on Bronchial Clearance in Humans

Roy E. Albert MD Institute of Environmental Medicine, New York University Medical Center, 10016, 550 First Ave, New York, NY
,
Harold T. Peterson Jr. MS Institute of Environmental Medicine, New York University Medical Center, 10016, 550 First Ave, New York, NY; Environmental Protection Agency, Rockville, Md
,
Daryle E. Bohning PhD Institute of Environmental Medicine, New York University Medical Center, 10016, 550 First Ave, New York, NY
&
Morton Lippmann PhD Institute of Environmental Medicine, New York University Medical Center, 10016, 550 First Ave, New York, NY
Pages 361-367 | Received 25 Jun 1974, Accepted 01 Nov 1974, Published online: 02 May 2013
 
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Abstract

The short-term effects of cigarette smoking on the bronchial clearance of inhaled monodisperse radioactive insoluble particles was studied in nine non-smokers and six smokers. Each subject inhaled two aerosols of the same particle size, tagged with a different isotope, with an interval of several hours between aerosol exposures. Simultaneous measurements were made of the clearance of both aerosols. Smoking of from two to seven cigarettes was started shortly after the second tagged aerosol.

Comparison of the bronchial clearance times of the two tagged aerosols gave a minimum estimate of a twofold transient speedup in deep bronchial clearance caused by the cigarette smoking in both smokers and nonsmokers.

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