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Abstract
No statistically significant correlation was observed between log δ-aminolevulinic acid dehydratase (ALAD) activity and blood lead levels (Pb-B) in rural or urban habitants (P > .5 and .P >.1, respectively) in whom no occupational source of lead was known. However, when the values of the two groups were pooled, there was a fairly good negative correlation (r = −0.509, P < .0 1 ). Stepwise correlation coefficient analysis indicated the existence of a threshold value of Pb-B (around 15 μg/100 ml) below which ALAD activity has nor orderly relationship with the Pb-B. In contrast with married couples, parents and their children showed a remarkably high interrelationship in values of ALAD. It is concluded that in low level lead exposure primarily genetic factors influence the activity of ALAD and, thus, ALAD is useful for the evaluation of lead exposure only when the lead level is higher than the threshold.
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