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Original Articles

Biochemical Effect of Ozone Exposure in Rats Exposed to Cigarette Smoke

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Pages 290-292 | Published online: 16 Apr 2013
 

Abstract

Rats were exposed to three cigarettes per day for 35 days, under realistic conditions. Pulmonary glucose-6-phosphate dehydrogenase (G-6-PD) activity in the exposed animals increased 27% over control values (P< .05). Subsequent exposure to acute, Mgh-dose ozone (3 ppm for 4 hr) decreased the augmented G-6-PD activities to near normal levels, whereas ozone exposures in animals not exposed to cigarette smoke caused mild decreases in pulmonary G-6-PD activities. The importance of these findings with respect to the susceptibility of the smoker to oxidant exposures is unknown.

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