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Original Articles

Lung Clearance of 4 μm Particles Coated with Silver, Carbon, or Beryllium

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Pages 58-62 | Published online: 16 Apr 2013
 

Abstract

Lung clearance in rabbits during the first week after inhalation of 4-fJm teflon particles tagged with chromium-51 and coated with silver, carbon, or beryllium was studied by external measurements of the radioactivity in the lungs. Ten rabbits were exposed to silverand carbon-coated particles on two separate occasions within 3 weeks. Clearances of the two types of particles were quite similar. Clearance in eight other rabbits that had inhaled silver-coated particles was quite similar to clearance in eight rabbits that had inhaled beryllium-coated particles. The result is regarded as evidence that alveolar macrophages do not play an active role in removing intact part icles from the lung the first week after inhalation.

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