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Original Articles

The Effect of Maternal Dose on Lead Retention in Suckling Rats

Pages 115-117 | Published online: 17 Apr 2013
 

Abstract

Lead (Pb) transfer from mother to litter was investigated at the late stage of lactation after a single intraperitoneal injection of 2.0 μg Pb/ml marked with 203Pb . After 48 hr almost 20% of the maternal dose of 203Pb was found in the litter, and about 0.6 and 0.2% of the injected dose was found in the liver and kidneys of suckling rats, respectively. Similar whole-body retention was observed earlier in suckling rats after a 20 times lower dose of stable lead was injected intravenously into their mothers.

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