Introduction of Iron Transport by a Potent Inducer of Aryl Hydrocarbon Hydroxylase, 2, 3, 7, 8—Tetrachlorodibenzo-p-dioxin

Abstract

A potent enzymatic inducer, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, stimulates iron transport in the intestine of the rat. The stimulatory site in the intestine is more

available to the inducer given orally than parenterally. Effects on intestinal absorptive mechanisms may be additional public health hazards of enzyme inducers such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin.