Postnatal Transfer of PCBs from Exposed Mothers to Their Babies: Influence of Breast-Feeding

ABSTRACT

Polychlorinated biphenyl (PCB) concentrations in the blood of mothers who were occupationally exposed to PCBs in a capacitor manufacturing facility, and their children, were analyzed from 1975 to 1979. The factory terminated PCB use in 1972, and environmental PCBs were eliminated artificially. Despite this, blood PCB levels of the mothers were very high, i.e., 10-100 times higher than that of non-occupationally exposed persons. In a previous report, we discussed the relationship between breast-feeding and PCB levels in the blood. This relationship is confirmed further by the present investigation which continued during a 5-yr period. The PCB levels in blood of children were influenced greatly by the duration of breast-feeding, but showed little relationship to the PCB levels in maternal blood. The PCB exposure period of the mothers, time of birth, and age of the children were less clearly related to the PCB levels in the children. The PCB concentration in the children's blood decreased at a constant rate and was independent of their blood PCB levels. A similar result was noted for their mothers' PCB levels. A slight difference, however, was found in the rate of decrease of blood PCB levels between the mothers and children. The results of questionnaire research on the health conditions and the medical examinations for the children showed that frequency of complaints, e.g., red eye, fever, itchy skin, and carious teeth, related favorably to the duration of breast-feeding. Less severe findings, i.e., decay of nails, pigmentation, mottled enamel, carious teeth, which were typical symptoms in Yusho patients, were observed in some children. They were not, however, diagnosed as having PCB poisoning inasmuch as medical treatments were unnecessary.