Carcinogenicity of Extract of Airborne Particles Using Newborn Mice and Comparative Study of Carcinogenic and Mutagenic Effect of the Extract

Yuko Sasaki Ph.D. Public Health and Hygiene Division, The Tokyo Metropolitan Research Institute for Environmental Protection, 1–7–5, Shinsuna, Koto-ku, Toyko 136, Japan

Toshio Kawai Public Health and Hygiene Division, The Tokyo Metropolitan Research Institute for Environmental Protection, 1–7–5, Shinsuna, Koto-ku, Toyko 136, Japan

Ken-Ichi Ohyama Public Health and Hygiene Division, The Tokyo Metropolitan Research Institute for Environmental Protection, 1–7–5, Shinsuna, Koto-ku, Toyko 136, Japan

Akiko Nakama Public Health and Hygiene Division, The Tokyo Metropolitan Research Institute for Environmental Protection, 1–7–5, Shinsuna, Koto-ku, Toyko 136, Japan

Ryuichi Endo Ph.D. Public Health and Hygiene Division, The Tokyo Metropolitan Research Institute for Environmental Protection, 1–7–5, Shinsuna, Koto-ku, Toyko 136, Japan

Abstract

An organic extract of airborne particles collected in Tokyo and its fractions (neutral, acidic, and basic) were investigated in Ames Salmonella assays for mutagenicity and in newborn mice for carcinogenicity. Mutagenicity to TA100 and TA98 strains was detected in the whole extract, the neutral, the acidic and the basic fractions with and without metabolic activation. In the carcinogenicity test, the incidence of lung tumor was as follows: whole extract, 4/25; neutral fraction, 7/25; acidic fraction, 0/20; basic fraction, 1/11; vehicle, 2/39; and uninjected, 3/47. The neutral fraction of the extract of the airborne particles showed highly potent mutagenicity and a high incidence of lung tumors in mice.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Carcinogenicity of Extract of Airborne Particles Using Newborn Mice and Comparative Study of Carcinogenic and Mutagenic Effect of the Extract

Information for

Open access

Opportunities

Help and information

Carcinogenicity of Extract of Airborne Particles Using Newborn Mice and Comparative Study of Carcinogenic and Mutagenic Effect of the Extract

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature