15
Views
36
CrossRef citations to date
0
Altmetric
Original Articles

Evaluation of the Perinatal and Postnatal Effects of Uranium in Mice upon Oral Administration

, , &
Pages 395-398 | Accepted 29 Apr 1989, Published online: 03 Aug 2010
 

Abstract

Perinatal and postnatal studies were performed in Swiss mice given uranium—as uranyl acetate dihydrate—at daily dosages of 0, 0.05, 0.5, 5, and 50 mg/kg from day 13 of pregnancy until weaning of the litters on day 21 post-birth. Postnatal development was monitored after 0, 4, and 21 d of lactation. At doses of 0, 0.05, 0.5, and 5 mg/kg · d, treatment with uranium had no significant effect on sex ratios, mean litter size, pup body weight, or pup body length throughout lactation. Significant decreases in the mean litter size on postnatal day 21, and in the viability and lactation indices were observed at the 50 mg/kg · d dose level. When comparing the “no observable effect level” (NOEL) for reproductive effects of uranium, with the concentrations of the metal usually ingested by men, a safety factor below 1 000 can be estimated.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.