Peripheral Sensory Neuropathy Associated with 1,1,1-Trichloroethane

Abstract

A case is described of peripheral sensory neuropathy in a woman who had daily exposure to 1,1,1-trichloroethane, used as a degreasing agent. Although previous reviews of the health effects of 1,1,1-trichloroethane have not indicated long-term neurotoxicity, there are recent animal studies that suggest chronic central neurotoxic effects and previous case reports of peripheral neuropathy in three exposed workers in one plant. Our case provides additional evidence that 1,1,1-trichloroethane exposure may be associated with peripheral sensory neuropathy. Reporting of similar cases is encouraged and investigation of the neurotoxic effects of 1,1,1-trichloroethane is recommended.