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Abstract
This study evaluated the relationship between central nervous system neoplasms (CNSN) and exposure to epichlorohydrin (ECH) among 11 CNSN cases and 44 controls who were members of a cohort of chemical workers. Information on area of employment and potential exposure to ECH was obtained from plant personnel and medical records and from interviews with long-term employees. An elevated odds ratio (OR) for CNSN was observed for subjects who worked in the epoxy resin process line (OR = ∞, 95% confidence interval [CI] = 1.2-∞), and in the production of anthraquinone intermediate dyes (OR = ∞, 95% CI = 1.7-∞) and azo dyes (OR = 3.6, 95% CI = 0.6–41). Routine potential exposure to ECH was associated with CNSN (OR = 4.2, 95% CI = 0.7–26). Dose-response relationships were found with duration and with cumulative routine potential exposure to ECH (p = .11 and .08, respectively). Acute exposure to ECH requiring treatment at the plant infirmary also was associated with subsequent CNSN (OR = ∞, 95% CI = 1.5-∞).
