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Abstract
1. Large doses of tungsten, administered to the chick either by injection or by feeding, increased tissue concentrations of tungsten and decreased tissue concentrations of molybdenum and tissue activities of xanthine dehydrogenase.
2. The rate of loss of large doses of tungsten from the liver occurred in an exponential manner with a half‐life of 27 h.
3. When tungsten was administered to chicks fed on a semi‐synthetic diet containing abnormally low concentrations of molybdenum, the activity of hepatic xanthine dehydrogenase was reduced to negligible levels.
4. The alterations in molybdenum metabolism resulting from the administration of large doses of tungsten to the chick appears to be the result of tungsten toxicity and not of molybdenum deficiency.
5. Deaths from tungsten toxicity occurred when tissue concentrations of tungsten were increased to approximately 25 μzg/g liver. At this tissue tungstencon centration the activity of xanthine dehydrogenase was zero.