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Physiology, biochemistry and neurobiology

Blood biochemical profiles in induced aflatoxicosis of cockerels

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Pages 155-160 | Accepted 24 Aug 1994, Published online: 09 Nov 2007
 

Abstract

1. Experimental intoxication induced in cockerels with varying doses of aflatoxin fed at the rate of 2.5 μg, 5.0 μg, and 10.0 μg per g of food resulted in appreciable changes in blood biochemical profiles.

2. At all doses the aflatoxin caused decreases in serum total proteins, albumin: globulin ratio, serum total cholesterol, serum calcium and phosphorus and increases in serum globulins, alanine amino transferase (ALT) and aspartate amino trans‐ferase (AST) concentrations.

3. No changes in serum bilirubin were observed.

4. Possible mechanisms for such blood biochemical changes are discussed and related to liver cellular damage caused by the aflatoxin toxicity.

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