Placental Transfer and Teratology of Pentachlorophenol in Rats

Robert V. Larsen Bionucleonics and Veterinary Anatomy Departments, Purdue University, West Lafayette, Indiana, 47907, USA

Gordon S. Born Bionucleonics and Veterinary Anatomy Departments, Purdue University, West Lafayette, Indiana, 47907, USA

Wayne V. Kessler Bionucleonics and Veterinary Anatomy Departments, Purdue University, West Lafayette, Indiana, 47907, USA

Stanley M. Shaw Bionucleonics and Veterinary Anatomy Departments, Purdue University, West Lafayette, Indiana, 47907, USA

David C. van Sickle Bionucleonics and Veterinary Anatomy Departments, Purdue University, West Lafayette, Indiana, 47907, USA

Abstract

Pentachloro[U-¹⁴C]phenol was administered orally to Charles River CD strain pregnant rats on day 15 of gestation. Concentrations found in the placentas and fetuses up to 32 hr remained very small indicating that the amount that passes through the placental barrier is negligible. Unlabeled compound was administered on days 8, 9, 10, 11, 12, and 13 of gestation. The incidence of resorptions in the treated animals was not significantly greater than that in the controls. Although malformations were observed, the number was minimal and could have been due to the toxic effects of the compound on the maternal rat.

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Placental Transfer and Teratology of Pentachlorophenol in Rats

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