Solubility studies of amlodipine besylate in ethylene glycol + ethanol mixtures at different temperatures

ABSTRACT

In the current work, the solubility of amlodipine besylate (ADB) was studied in the ethylene glycol + ethanol at different temperatures (293.2-313.2 K). The experimental solubility data obtained herein were correlated with some well-known cosolvency models and the accuracy of these models was investigated with the mean relative deviations of the back calculated data. The apparent thermodynamic parameters (Gibbs energy, enthalpy and entropy) of ADB in the non-aqueous saturated mixtures were also calculated with the van’t Hoff and Gibbs equations at T_hm.

GRAPHICAL ABSTRACT

KEYWORDS:

• Amlodipine besylate
• solubility
• cosolvency models
• thermodynamic parameters

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Acknowledgements

This work was supported by the Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran under grant number 67770.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article was originally published with errors, which have now been corrected in the online version. Please see Correction (https://doi.org/10.1080/00194506.2024.2359175)

Additional information

Funding

This work was supported by Tabriz University of Medical Sciences [grant number: 67768].