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Section B

Dengue disease, basic reproduction number and control

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Pages 334-346 | Received 05 Sep 2010, Accepted 10 Jan 2011, Published online: 03 Jun 2011
 

Abstract

Dengue is one of the major international public health concerns. Although progress is underway, developing a vaccine against the disease is challenging. Thus, the main approach to fight the disease is vector control. A model for the transmission of dengue disease is presented. It consists of eight mutually exclusive compartments representing the human and vector dynamics. It also includes a control parameter (insecticide) in order to fight the mosquito. The model presents three possible equilibria: two disease-free equilibria (DFE) and another endemic equilibrium. It has been proved that a DFE is locally asymptotically stable, whenever a certain epidemiological threshold, known as the basic reproduction number, is less than one. We show that if we apply a minimum level of insecticide, it is possible to maintain the basic reproduction number below unity. A case study, using data of the outbreak that occurred in 2009 in Cape Verde, is presented.

2010 Mathematics Subject Classifications :

Acknowledgements

Work partially supported by Portuguese Foundation for Science and Technology (FCT) through the PhD Grant SFRH/BD/33384/2008 (Rodrigues) and the R&D units Algoritmi (Monteiro) and CIDMA (Torres). The authors are very grateful to three referees, for valuable remarks and comments, which have contributed significantly to the quality of the paper.

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