SOMATOSENSORY EVOKED POTENTIAL AND HISTOPATHOLOGICAL INVESTIGATIONS IN ISCHAEMIA-INDUCED BRAIN DAMAGE: EFFECTS OF TRIMETAZIDINE IN RATS

ATILLA OGUZHANOGLU Pamukkale University, Medical School, Department of Neurology, Denizli, Turkey

TÜLAY KURT Pamukkale University, Medical School, Department of Neurology, Denizli, Turkey

RAGIP ORTAÇ Behçet Uz Child Hospital, Izmir, Turkey

BÜLENT TURMAN University of Sydney, Department of Biomedical Sciences, Faculty of Health Sciences, Sydney, Australia

Abstract

We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage.

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SOMATOSENSORY EVOKED POTENTIAL AND HISTOPATHOLOGICAL INVESTIGATIONS IN ISCHAEMIA-INDUCED BRAIN DAMAGE: EFFECTS OF TRIMETAZIDINE IN RATS

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SOMATOSENSORY EVOKED POTENTIAL AND HISTOPATHOLOGICAL INVESTIGATIONS IN ISCHAEMIA-INDUCED BRAIN DAMAGE: EFFECTS OF TRIMETAZIDINE IN RATS

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