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Abstract
The study assessed the biochemical differences between right hemispheric dominant and left hemispheric dominant individuals detected by handedness and the dichotic listening test. The isoprenoid metabolites--digoxin, dolichol, and ubiquinone, glycoconjugate metabolism, free radical metabolism, and the RBC membrane composition were studied in individuals with differing hemispheric dominance. The results showed that all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals had increased HMG CoA reductase activity, elevated digoxin and dolichol levels. The serum magnesium, RBC membrane Na+-K+ ATPase activity and serum ubiquinone levels were reduced in all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals. The tryptophan-derived neurotransmittors--serotonin, quinolinic acid, strychnine, and nicotine--were increased while the tyrosine derived neurotransmittors--dopamine, noradrena1ine, and morphine--were reduced in all right hemispheric dominant individuals and 50% of left hemispheric dominant individuals. The other 50% of left hemispheric dominant individuals had decreased HMG CoA reductase activity, reduced digoxin, and dolichol levels. The serum magnesium, RBC membrane Na+-K+ ATPase activity, and serum ubiquinone levels were increased in this group. The tryptophan derived neurotransmittors--serotonin, quinolinic acid, strychnine, and nicotine were reduced, while the tyrosine-derived neurotransmittors--dopamine, noradrenaline, and morphine--were increased in the rest (50% of left hemispheric dominant individuals). Hemispheric dominance detected by the dichotic listening test and handedness has no correlation with cerebral chemical dominance.