FLUOXETINE ALTERS MU OPIOID RECEPTOR EXPRESSION IN OBESE ZUCKER RAT EXTRAHYPOTHALAMIC REGIONS

ITZIAR CHURRUCA Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain

MARÍA P. PORTILLO Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain

JOSÉ MARÍA ZUMALABE Department of Personality, Evaluation and Psychological Treatments Faculty of Pharmacy University of the Basque Country, Vitoria, Spain

MARÍA T. MACARULLA Department of Nutrition and Food Science, Faculty of Pharmacy University of the Basque Country, Vitoria, Spain

LAURA SÁENZ DEL BURGO Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain

JON ZARATE Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain

ENRIQUE ECHEVARRÍA Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria, Spain

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Abstract

The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions. Male obese Zucker (fa/fa) rats were administered with fluoxetine (10 mg/kg; i.p.) daily for two weeks. Brain regional immunostaining for mu opioid receptor was carried out. An increase in the numbers of neural cells immunostained for mu opioid receptor in caudatus-putamen, dentate gyrus, lateral septum, amygdala, and frontal, parietal, and piriform cortices was observed. Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.

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FLUOXETINE ALTERS MU OPIOID RECEPTOR EXPRESSION IN OBESE ZUCKER RAT EXTRAHYPOTHALAMIC REGIONS

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FLUOXETINE ALTERS MU OPIOID RECEPTOR EXPRESSION IN OBESE ZUCKER RAT EXTRAHYPOTHALAMIC REGIONS

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