CALBINDIN D-28k IMMUNOREACTIVITY INCREASES IN THE HIPPOCAMPUS AFTER LONG-TERM TREATMENT OF SOY ISOFLAVONES IN MIDDLE-AGED OVARIECTOMIZED AND MALE RATS

IN KOO HWANG Department of Anatomy College of Medicine, Hallym University, Chunchon, South Korea

YOON-BOK LEE Department of Laboratory Animal Research Central Research Instititue, Dr. Chung's Food Co., Ltd., Cheongju, South Korea

KI-YEON YOO Department of Anatomy College of Medicine, Hallym University, Chunchon, South Korea

TAE-CHEON KANG Department of Anatomy College of Medicine, Hallym University, Chunchon, South Korea

SOON SUNG LIM Division of Life Science and Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea

HEON-SOO SOHN Department of Laboratory Animal Research Central Research Instititue, Dr. Chung's Food Co., Ltd., Cheongju, South Korea

SANG MOO KIM Faculty of Marine Bioscience and Technology, Kangnung National University, Kangnumg, South Korea

WOO-JUNG KIM Faculty of Food Science & Technology, College of Life Sciences Sejong University, Seoul, South Korea

HYUN KYUNG SHIN Division of Life Science and Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea

MOO HO WON Department of Anatomy College of Medicine, Hallym University, Chunchon, South Korea

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Abstract

This article investigates the long-term effects of soybean isoflavones (ISO) on the changes of calbindin D-28k (CB) immunoreactivity in the hippocampus in middle-aged ovariectomized female rats as well as middle-aged control female and male rats to identify any correlation between calcium and phytoestrogens. In the CA1 region, CB immunoreactivity in the ovariectomized females was similar to that of the control females, whereas CB immunoreactivity in the males was significantly lower than that of the control females. In the dentate gyrus, CB immunoreactivity in the ovariectomized females and males was significantly lower than that of the control females. CB immunoreactivity in all groups was increased dose-dependently after ISO treatment in the CA1 region and dentate gyrus. This result suggests that ISO treatment enhances the expression of CB immunoreactivity in the hippocampus in the middle-aged rats.

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CALBINDIN D-28k IMMUNOREACTIVITY INCREASES IN THE HIPPOCAMPUS AFTER LONG-TERM TREATMENT OF SOY ISOFLAVONES IN MIDDLE-AGED OVARIECTOMIZED AND MALE RATS

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CALBINDIN D-28k IMMUNOREACTIVITY INCREASES IN THE HIPPOCAMPUS AFTER LONG-TERM TREATMENT OF SOY ISOFLAVONES IN MIDDLE-AGED OVARIECTOMIZED AND MALE RATS

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